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Amyloid Beta (1-43) (FL) Aβ

$805.00
SKU:
27710
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Solid phase sandwich ELISA for the determination of human Amyloid Beta (1-43) Aβ in cerebrospinal fluid, brain extract of Tg mouse and cell culture supernatant. For research use only, not for use in diagnostic procedures.<br><br>
The first case of Alzheimer's disease (AD) was defined and reported in 1907 by the German scientist, Dr. A. Alzheimer. His studies have shown that this is the main cause of dementia in the elderly. The plaques which appear in the brains of individuals who suffer AD are mostly constituted by the Amyloidβ protein (Aβ). Aβ is a peptide which consists of 40 or 42 (43) amino acids, and reports show that this is cleaved from β- and γ- secretase from the amyloid precursor protein. APP is a trans-membrane protein consisting of 695, 751, or 770 amino acids. Reports have shown many variants of Aβ exist and are clarified into the culture supernatant from the APP cDNA transfected mouse neuroblastoma cell. Many types of Aβ molecules are targeted in AD research. A process, Aβ40 is produced by cleaving from Aβ49 through Aβ46 and Aβ43, has been reported in tripeptide hypothesis, partly for that reason the interest in Aβ43 molecules has been growing. This kit can measure full-length (FL) molecules of Human Aβ (1-43).<br><br>

Keywords:
Alzheimer's Disease / Amyloid β / Amyloid-β / Amyloid Beta / Aβ / Beta Amyloid

Assay Description:
Overnight incubation (4°C) + 1 hour (4°C) + 30 min. (RT) = Overnight + 1 hour, 30 min. total incubation time.
Catalog number:
27710
configuration:
96 Determinations, 12x8 removable strips.
controls:
None provided.
design:
Solid phase sandwich ELISA using 2 kinds of highly specific antibodies.
FDA Status:
For research use only, not for use in diagnostic procedures.
MSDS:

Click for MSDS

notes:
The protocol for this product (see above) is intended to serve as an example only. Please refer to the Instructions For Use provided with the assay kit for precise details.
Other names:
Aβ, Amyloid beta, A-beta.
Protocol:

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Sample types:
Cerebrospinal fluid, brain extract of Tg mouse and cell culture supernatant.
Sample volume:
100 μL of properly diluted unknown / determination.
standards:
8 standards, serially diluted from 1 prepared lyophilized standard.
Standard range:
0 / 2.34 - 150 pg/mL
storage:
2 - 8°C
sensitivity:
Please see protocol for assay-specific performance characteristics.
Species:
Human
Additional info:

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References:

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