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Nephrology

Nephrology is the branch of medicine and research that deals with the physiology and diseases of the kidneys.

The Renin-Angiotensin-Aldosterone System (RAAS) also known as the Renin-Angiotensin System (RAS) is a multi-hormonal system that coordinates a variety of physiological processes for proper regulation of blood volume and pressure.

RAAS regulates sodium and water absorption in the kidney, thus directly impacting systemic blood pressure.

Typically, RAAS is activated when a drop in blood pressure occurs (reduced blood volume) to increase water and electrolyte reabsorption in the kidneys, which compensates for the drop in blood volume; thus, increasing blood pressure.

When renin is released into the blood, it acts upon a circulating substrate, angiotensinogen, that undergoes proteolytic cleavage to form the decapeptide angiotensin I. Vascular endothelium, particularly in the lungs, has an enzyme, angiotensin converting enzyme (ACE), that cleaves off two amino acids to form the octapeptide, angiotensin II (AII), although many other tissues in the body (heart, brain, vascular) also can form AII.

The one-dimensional standard of kidney disease detection is incompatible with the complexity of renal pathology. The diagnosis of kidney disease has largely focused on glomerular filtration, while assessment of kidney tubular health has notably been absent. Kidney tubular cells undergo a cascade of cellular responses that result in the production and accumulation of low-molecular-weight proteins in the urine and systemic circulation. Recent advancements in molecular analysis and proteomics have allowed the identification and quantification of these proteins as biomarkers for researching and characterizing kidney diseases.

This category is comprised of unique biomarker ELISA kits that support research in the broad spectrum of acute to chronic kidney diseases.

  • ACE

    ACE

    Sandwich enzyme-linked immunosorbent assay (ELISA) for the determination of Angiotensin-converting enzyme (ACE) in human serum, plasma, body fluids, tissue lysates or cell culture supernates. For research use only, not for use in diagnostic procedures.

    $661.00
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  • ACE2

    ACE2

    The Human Angiotensin-converting enzyme 2 (ACE2) ELISA has been designed for the  detection of human ACE2 in serum, plasma, tissue homogenates or other biological fluids. For research use only, not for use in diagnostic...

    $683.00
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  • Aldosterone ELISA

    Aldosterone ELISA

    Competitive enzyme-linked immunosorbent assay (ELISA) for the determination of Aldosterone in serum, plasma or urine. For research use only, not for use in diagnostic procedures.

    $386.00
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  • Aldosterone RIA

    Aldosterone RIA

    Radioimmunoassay for the determination of Aldosterone in human serum and urine. For research use only, not for use in diagnostic procedures.

    $432.00
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  • Angiotensin II

    Angiotensin II

    Radioimmunoassay (RIA) for the determination of angiotensin II in EDTA plasma. For research use only, not for use in diagnostic procedures.

    $873.00
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  • Angiotensinogen (104AT 601.2.80) Anti-Human Mouse IgG MoAb

    Angiotensinogen (104AT 601.2.80) Anti-Human Mouse IgG MoAb

    Angiotensinogen is the precursor of angiotensin and is cleaved into angiotensin I and II in the renin-angiotensin system, and it has long been reported to play an important role in controlling blood pressure. In recent years interest related to the role...

    $550.00
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  • Angiotensinogen (Total)

    Angiotensinogen (Total)

    Angiotensinogen. Solid phase sandwich ELISA for the determination of human Total Angiotensinogen in serum, EDTA-plasma, urine, or cell culture media. For research use only, not for use in diagnostic procedures.<br><br> Angiotensinogen is the...

    $827.00
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  • Anti-Osteopontin N-Half (34E3) Mouse IgG MoAb

    Anti-Osteopontin N-Half (34E3) Mouse IgG MoAb

    Osteopontin (OPN) is a secreted glycoprotein that was originally isolated from bone. Its molecular weights have been reported in the range of 66 kDa to 44 kDa depending on glycosylation and phosphorylation. OPN is also known to be expressed in other...

    $550.00
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  • Anti-Osteopontin N-Half (34E3) Mouse IgG MoAb 1

    Anti-Osteopontin N-Half (34E3) Mouse IgG MoAb 1

    Osteopontin (OPN) is a secreted glycoprotein that was originally isolated from bone. Its molecular weights have been reported in the range of 66 kDa to 44 kDa depending on glycosylation and phosphorylation. OPN is also known to be expressed in other...

    $132.00
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