behars Loading... Please wait...

Alpha Klotho ELISA Kits

Alpha Klotho (α-Klotho) is a key player that integrates a multi-step regulatory system of calcium metabolism and phosphate homeostasis.

Alpha Klotho (α-Klotho) was identified as an extremely down-regulated gene in the genetic mutation mouse (Klotho mouse) of which phenotype is very similar to various symptoms of human aging. Then, the sequences of Alpha Klotho (α-Klotho) genes have been identified in various species including human based on the one of mouse. α-Klotho protein is a 130kDa, one-transmembrane protein and its expression is confirmed in the kidneys and the parathyroid glands. In recent years, it has become clear that α-Klotho is an important molecule within a living organism regulating the metabolism of mineral such as calcium and phosphorus. Therefore, it is considered that, in Klotho mouse, early aging-like symptoms are induced by impaired mineral homeostasis caused by decreased expression of α- Klotho. Meanwhile, it is reported that the long N-terminal extracellular domain which comprises the major portion of sequence of α-Klotho protein is released free into blood by shedding. However, there are may unclear points about functions and changes in concentration of free (soluble) α-Klotho protein, so it has been required to develop the measurement system of α-Klotho.

We offer a solid phase sandwich ELISA for the determination of human soluble Alpha Klotho (α-Klotho) in serum and EDTA-plasma and a solid phase sandwich ELISA for the determination of mouse soluble Alpha Klotho (α-Klotho) in mouse urine.

For research use only, not for use in diagnostic procedures.

Click for Product Brochure

View As Grid List
View As Grid List

OUR ASSAY KIT CATEGORIES

Back to Top