Napsin A (TMU-Ad02) Anti-Human Mouse IgG MoAb

A new protein isolated by two-dimensional immuno-electrophoresis from tissue of lung adenocarcinoma was identified as Napsin A, a new aspartic Proteinase. The reactivity of the antibody showed immunohistochemically in type II pneumocytes, alveolar macrophages, renal tubules and exocrine glands and ducts in pancreas. In particular, type II pneumocytes and alveolar macrophages showed strong staining. The specificity of the antibody is very interesting, which in primary lung adenocarcinoma, 47 out of 58 (81.0%) primary lesions were positive. All well-differentiated adenocarcinoma except those of goblet type showed strong staining. The antibody may be a useful tool as a tumor marker for primary lung adenocarcinoma. For research use only, not for use in diagnostic procedures.