A plasma fibronectin is present in plasma at high concentrations and plays roles in blood coagulation and wound healing. The fibronectin from plasma has been used as a cell-adhesive substrate (a coating material) for cultured cells. However, the fibronectin is derived from animal or human plasma, therefore, has risks of blood-borne infections.<br><br>
Fibronectin Neosilk®, Plasma is a recombinant human fibronectin which is produced by transgenic silkworms as a homodimer of a plasma-abundant splicing variant, EDA-, EDB- and IIICS+. This recombinant fibronectin has the cell-adhesive activity comparable with or more than that of natural plasma fibronectin, and has a specific feature of free from animal derived materials. This product can be used as a coating material for various cultured cells including mesenchymal stem cells.