Novel cardiovascular biomarker modulating hearts calcium regulation.

Secretoneurin (SN) is associated with biological processes linked to heart cell calcium, a key mechanism in the regulation of heart rhythm^1,2 This in contrast to other commonly used biomarkers such as cardiac troponins and N-terminal proB-type natriuretic peptide (NT-proBNP). This unique biological function may explain why SN has been shown to be an independent and strong predictor of mortality in all major patient cohorts tested, including patients with chronic heart failure, ventricular arrhythmia, acute heart failure, and acute respiratory failure patients with CVD and severe sepsis^3,4,5,6

Secretoneurin (SN) - Biomarker of Cellular Calcium Imbalance

Existing technologies to achieve HF risk stratification and their limits

Secretoneurin (SN) is a 33-amino acid neuropeptide produced by the endoproteolytic cleavage of the proprotein secretogranin II (amino acids 154-186), a member of the chromogranin-secretogranin protein family. SN is produced by neuroendocrine- and heart muscle cells and is detectable in the blood stream.