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Trends in Drug Development for Hyperlipidemia

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Problem - Risk of a Cardiovascular Event 

While cholesterol control has been dramatically improved, widely used drugs such as statins, Ezetimibe and PCSK9 inhibitors have not substantially decreased the risk of a cardiovascular event.

Significance of TG Control 

A recent study highlights the significance of triglyceride (TG) control. New drug development that inhibits regulating factors of LPL activity that is critical for TG metabolism has been progressing on a fast track.

Future Drug Development (Angptl3, ApoC3, Angptl4 and Angptl8 inhibitors)

The factors that negatively regulate LPL activity like Angptl3 inhibitors and recent hot topics “the development of ApoC3 inhibitors” have been actively discussed by researchers. It is expected that drug development might be focused on Angptl4 inhibitors and/or Angptl8 inhibitors in near future.

Possible Drug Development Target (ApoA5 and GPIHBP1) 

Factors that positively regulate LPL activity like ApoA5 or GPIHBP1 might be targeted for drug development for the purpose of TG controls. It is especially suggested by genome analysis that ApoA5 could be an important risk factor for early-onset myocardial infarction as much as LDL receptors.

Lipid Metabolism Related Products

IL-36γ and IL-37 Cytokine ELISAs

ELISA Kit for IL-36γ (Specific Marker for Psoriasis)  IL-36γ is a specific marker for Psoriasis. This assay is highly specific for human IL-36γ. Does not cross-react with human IL-36α and IL-36β. Sensitivity: 3 pg/ml | Range: 3.9 to 250 pg/ml | Sample: Serum, Cell Culture Supernatant IL-36α (IL-1F6), IL-36β (IL-1F8) and IL-36γ (IL-1F9) are members of the IL-1 [...]

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Reliable Catecholamines ELISAs for Plasma and Urine Samples

Epinephrine (Adrenaline), Norepinephrine (Noradrenaline) together with Dopamine constitute the group of catecholamines, which play an important role as hormones and neurotransmitters. After they have exerted their effects, the catecholamines are broken down via intermediate products (Metanephrine, Normetanephrine, 3-Methoxytyramine respectively) and finally excreted in urine. Diseases which are associated with altered levels of catecholamines include hypertonia, degenerative [...]

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Relationship Between Antiplatelet Agent (Cilostazol) and Plasma Inflammatory Factor APP770

We are pleased to introduce a new publication with regard to the relationship between the effects of the antiplatelet agent (Cilostazol) and plasma inflammatory factor APP770.The research team led by Dr. Naoki Saji MD, PhD, vice head of the Center for Comprehensive Care and Research on Memory Disorders, National Center for Geriatrics and Gerontology - Japan, [...]

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​Galactose-deficient IgA1 (Gd-IgA1) as a Biomarker for IgA Nephropathy

Galactose-deficient IgA1 (Gd-IgA1) attracts a lot of attention as a critical effector molecule in the pathogenesis and progression of IgA nephropathy (IgAN) in many recent studies. It is suggested that several O-link glycans modified regions exist in the heavy chain hinge region of human IgA1 molecules and Gd-IgA1 circulates in blood stream of the patients with [...]

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Free 25-Hydroxyvitamin D Is Associated With the Risk of Mortality in Subjects With Coronary Artery Disease (CAD)

Dr. Yu recently published a paper entitled “Serum Bioavailable and Free 25-Hydroxyvitamin D Levels, but Not ItsTotal Level, Are Associated With the Risk of Mortality in Patients With Coronary Artery Disease" (Circulation Research. 2018;123:996–1007).A cohort of 1387 subjects with angiographically confirmed CAD was followed up during 6.7 years, and total 25OH Vitamin D, Bioavailable 25OH Vitamin D, and Free 25OH [...]

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Poster Session: Urinary Gd-IgA1 Represent a Disease-Specific Marker of IgA Nephropathy

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Visit Us at the 2018 Society for Neuroscience Annual Meeting

Society for Neuroscience's 48th annual meeting, Neuroscience 2018, is the world’s largest neuroscience conference for scientists and physicians devoted to understanding the brain and nervous system. Neuroscience 2018 is where neuroscientists collaborate and network with peers, learn from experts, explore the newest neuroscience tools and technologies, and discover great career opportunities. Join more than 30,000 colleagues from [...]

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Visit Us at ASN Kidney Week 2018

Join our team and more than 13,000 other kidney professionals from across the globe at Kidney Week 2018 in San Diego, CA. The world's premier nephrology meeting, Kidney Week provides participants exciting and challenging opportunities to exchange knowledge, learn the latest scientific and medical advances, and listen to engaging and provocative discussions with leading experts [...]

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Influence Of HAMA And The Requirement Of SPE In Measurement Of Active GLP-1

The accurate measurement of active GLP-1 in blood is considered critical for basic and clinical research of diabetes.Measuring active GLP-1 in blood without the influence of non-specific reactions made by Heterophilic Antibodies (HA), especially HAMA (Human Anti-Mouse Antibodies) is required for obtaining accurate active GLP-1 values and Solid-Phase Extraction: SPE pre-treatment is typically needed. However, [...]

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