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Evaluation of an Automated Assay for the Measurement of LPL and HL Activity

July 13, 2018

Mar 23, 2018 1:50:52 AMWe are proud to announce our collaboration with Pacific Biomarkers on their abstract: Performance Evaluation of an Automated Assay for the Measurement of LPL and HL Activity. The following poster will be presented at the AACC.

Title: Performance Evaluation of an Automated Assay for the Measurement of LPL and HL Activity

Poster Number: B-158
Date: Wednesday, August 1st, 2018
Session Time: 12:30 – 1:30 PM
Session: 12 / Lipids / Lipoproteins
Presented by: Pacific Biomarkers (https://pacbio.com) and IBL

Related Products:

LPL/HTGL Activity Assay Kit (Cat #27185)

LPL/HTGL Activity Plus Control Assay Kit (Cat #27264)

Visit IBL-America booth #4462 to learn more or contact us!

​Galactose-deficient IgA1 (Gd-IgA1) as a Biomarker for IgA Nephropathy

July 12, 2018

Galactose-deficient IgA1 (Gd-IgA1) attracts a lot of attention as a critical effector molecule in the pathogenesis and progression of IgA nephropathy (IgAN) in many recent studies.

It is suggested that several O-link glycans modified regions exist in the heavy chain hinge region of human IgA1 molecules and Gd-IgA1 circulates in blood stream of the patients with the pathological condition of IgAN.

The measuring system using snail (helix aspersa; HAA) lectin has been used in numerous past studies and revealed that serum levels of Gd-IgA1 in patients with IgAN is significantly elevated compared with the level of healthy subjects or patients with renal diseases other than IgAN. Thus, the importance and purpose of measuring serum Gd-IgA1 levels has been gradually recognized.

However, since the measuring system using HAA lectin is not suitable for measuring multiple and massive samples in large scale studies due to its instability of glycan-recognizing activity, development of alternative measuring system that can quantitatively measure human Gd-IgA1 in serum with stable and reliable data has been considered an essential and urgent matter. The IBL Galactose-deficient IgA1 (Gd-IgA1) ELISA kit uses a monoclonal antibody that specifically recognizes galactose-deficient hinge sequences of human Gd-IgA1. It is a lectin non-dependent measuring system that can measure Gd-IgA1 in human serum and EDTA-plasma and is also suitable for large scale studies because of its stability.

More information:

Galactose-deficient IgA1 (Gd-IgA1) ELISA kit - Cat# 27600

Gd-IgA1 (KM55) Anti-Human Rat IgG Monoclonal Antibody - Cat #10777

Expand Your Gastroenterology Stool Testing Offerings

June 20, 2018

This new product range includes ELISA tests for the detection of different viral, bacterial and parasitic antigens in fecal samples. These assays are for research use only - not for use in diagnostic procedures.

Product NameCatalog Number
Verotoxin 1+2 (Shiga Toxin 1+2) ELISA


Norovirus ELISA


Giardia lamblia ELISA


Cryptosporidium parvum ELISA


Clostridium difficile GDH ELISA


Clostridium difficile (Toxin A + B) ELISA


Astrovirus ELISA


Contact us for more information.

New Publication Suggests Free Vitamin D May Better Reflect Vitamin D Status in Pregnancy

June 14, 2018

On March 19th, 2018, Hocher et al. published a paper entitled "Reference intervals for measured and calculated free 25-hydroxyvitamin D in normal pregnancy." showing that Free 25(OH) Vitamin D may better reflect the 25OH Vitamin D status in normal pregnancy.

This is the result of the largest study comparing free- and total 25(OH) Vitamin D during pregnancy. The following differences were found between both measurements:

  • Free 25(OH)D significantly lowers in the 3rd trimester comparing to the 1st trimester, whereas total 25(OH)D was not decreased in late pregnancy.
  • Free 25(OH)D was significantly correlated with serum calcium, whereas total 25(OH)D was not.
  • Free 25(OH)D better correlated with serum bone-specific alkaline phosphatase than total 25(OH)D.

The group established pregnancy trimester-specific reference intervals for free 25(OH)D, and claimed that the measurement of free 25(OH)D in pregnant women is suitable as a novel laboratory parameter for vitamin D status monitoring during human pregnancy and might replace routine total 25(OH)D assessment in the future.

More and more studies support the importance of free 25(OH) Vitamin D, suggesting that this fraction of 25(OH) Vitamin D may be a better measurement of Vitamin D status rather than the total 25(OH) Vitamin D in pregnancy, renal disease, liver disease and intensive care units.

More information: Free 25(OH) Vitamin D ELISA

NEW Product | Autoantibodies to Insulin (IAA) RIA

June 5, 2018

Mar 23, 2018 1:50:52 AMWe are pleased to announce the release of our IAA RIA Kit (Cat# KIRM2035) for the determination of Autoantibodies to Insulin (IAA) in human serum. This radioimmunoassay is for research use only and not for use in diagnostic procedures.

Type 1 diabetes, also known as insulin-dependent diabetes mellitus (IDDM), results from a chronic autoimmune destruction of the insulin-secreting pancreatic beta cells, probably initiated by exposure of genetically susceptible host to an environmental agent. Autoimmune destruction of beta cells is thought to be completely asymptomatic until 80-90% of the cells are lost. This process may take years to complete and may occur at any time in all ages. The presence of Insulin autoantibodies (IAA) in samples never treated with insulin, as opposed to insulin antibodies (IAb), is evidence of ongoing destruction process of pancreatic beta cells in type 1 diabetes. IAA are particularly important when determining type 1 diabetes risk since their prevalence is significantly elevated in subjects developing the disease in childhood and moreover, they are often the first autoantibodies to be detected before onset of the disease. The prevalence of IAA is inversely correlated with the age of diagnosis. In type 1 diabetics with recent onset of the disease in the age < 5 years IAA can be determined in > 90 % of the samples, whereas in type 1 diabetics in the age > 20 years the prevalence of IAA is < 20 %. As concluded by the Fourth International Workshop for Insulin Autoantibody (IAA) Standardization (1992), liquid-phase assays such as radio-binding assay - RIA is the method of choice - detect IAA of higher predictive value for type 1 diabetes as ELISA. The IAA measurement, together with that of antibodies to glutamic acid decarboxylase (GAD65 Ab), protein tyrosine phosphatase-like antigen IA2 forms the basis of current strategies for predicting future onset of type 1 diabetes.

More information: IAA RIA Kit (Cat# KIRM2035)