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New USF Study Uses IBL-America's Amyloid Beta 1-40 and 1-42 ELISA Kits

June 22, 2017

A new publication by the University of South Florida using IBL-America's Amyloid Beta 1-40 and Amyloid Beta 1-42 ELISA kits has been released:

LISPRO mitigates β-amyloid and associated pathologies in Alzheimer's mice

A Habib, D Sawmiller, S Li, Y Xiang, D Rongo, J Tian… - Cell Death & Disease, 2017

...Enzyme-linked immmunosorbent assay (ELISA) was performed according to the manufacturer’s instruction. Total Aβ species, including Aβ40,42 in cell conditioned media and brain homogenates were detected by Aβ1–40/42 ELISA kits (IBL America, Minneapolis MN, USA) according to the manufacturer’s instructions...

More information about the assays:

Amyloid Beta ( 1-40 ) Aβ ELISA (Cat# 27713)

Amyloid Beta ( 1-42 ) Aβ ELISA (Cat# 27711)

New Release! Mouse/Rat Intact Proinsulin ELISA Kit

June 6, 2017

#27706 Mouse/Rat Intact Proinsulin Assay Kit has been released. Proinsulin is a precursor of insulin that is synthesized in the β cells of the islet of Langerhans of pancreas. Most of the proinsulin synthesized in the rough endoplasmic reticulum of β cells is stored in the secretory granules. Proinsulin is cleaved by prohormone converting enzyme (PC) 1/3 at the junction of the C-peptide with the B-chain of insulin, subsequently it is cleaved by PC2 at the junction of the C-peptide with the A-chain of insulin, consequently it is divided into insulin that consists of 21 amino-acid A chain and 30 amino-acid β chain and c-peptide that consists of 33 amino acid. It has been considered that the conversion rate from proinsulin to insulin in type 2 diabetes patients decreases due to dropping down of PC1/3 enzymatic activity by abnormal function of pancreatic β cells. Thus, intact proinsulin level in blood or the ratio of intact proinsulin and insulin (P/I ratio) can be considered to become a potential biomarker that reflects functional change of the PC1/3 activity at pancreaticβ cell. It has been especially known that the P/I ratio is a valuable pancreatic β cell evaluation method that does not require a loading test as it can be measured using blood samples in fasting.

This ELISA kit can be used for measuring intact proinsulin, not including cleaved intermediate products, in mouse and rat samples. For research use only - not for use in diagnostic procedures.

Catalog Number27706
SpeciesMouse/Rat
DesignSandwich enzyme-linked immunosorbent assay (ELISA) technique.
Standards7 standards
ControlsNone provided.
Sample TypesSerum, EDTA-plasma, and cell culture supernatant.
Sample Volume20 μL
Assay Desc.Overnight (2-8°C) + 1 hour (2-8°C) + 30 min. (RT) = Overnight + 1 hour, 30 min. total incubation time.
Standard Range14.1 - 900 pg/mL
Sensitivity6.83 pg/mL

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Introducing A NEW Drug Monitoring Assay | Anti-Vedolizumab (Entyvio®)

May 31, 2017

This message is to inform you about a new development concerning our ImmunoGuide® Drug Monitoring product range.

We are pleased to present our new Anti-Vedolizumab (Entyvio®) ELISA kit!

The drug Vedolizumab (trade name Entyvio®) is a humanised immunoglobulin G1 monoclonal antibody that binds exclusively to the lymphocyte integrin α4β7, is indicated for the treatment of moderately to severely active ulcerative colitis [UC] or Crohn’s disease [CD]. During treatment the presence of persistent anti-Vedolizumab antibody was observed to substantially reduce serum concentrations of Vedolizumab, either to undetectable or negligible levels. The ImmunoGuide Antibody to Vedolizumab ELISA kit has been designed for the measurement of free antibodies against this drug. It does not detect such antibodies which already are bound to the drug.

Enzyme immunoassay for the semi-quantitative determination of free antibodies to Vedolizumab (Entyvio®) in serum and plasma. For research use only - not for use in diagnostic procedures.

Catalog NumberIG-BB116
SpeciesHuman
DesignEnzyme immunoassay (ELISA) technique.
StandardsNegative control is used to determine a cut-off value for the evaluation of results.
ControlsPositive and negative controls, ready to use.
Sample TypesSerum and plasma.
Sample Volume10 µL
Assay Desc.1 hour incubation (RT) + 1 hour (RT) + 15 min. (RT) = 2 hour, 15 min. total incubation time.
Standard RangeNegative control is used to determine a cut-off value for the evaluation of results.
Sensitivity10 ng/mL
Storage2 - 8 °C

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Visit Us At The Duke University BioResearch Product Faire

May 18, 2017

Visit Us At This Show And Discover How IBL-America Can Help You Achieve Your Research Goals!

Come help us celebrate our 20 year anniversary! We provide researchers with high quality ELISA kits, RIA kits, Antibodies and Proteins.

18th Annual

Thursday, May 25, 2017

10:00 AM - 2:30 PM

Searle Conference Center Lecture Hall

Duke University

Contact us to schedule a meeting or stop on by the show!

Alternatives to DiaSorin and Siemens Discontinued RIA Assays

May 17, 2017

Some diagnostic companies have recently made the decision to stop manufacturing RIA assays, mainly as this specialty field no longer fits in their long-term strategic business plans. Examples are: Siemens Healthcare Diagnostics Products has decided to no longer support the full DPC Coat-A-Count RIA product line and DiaSorin, who stopped production of the majority of their RIA products.

This means that assistance in resolving method-related issues for these RIA products will no longer be available within Siemens or DiaSorin either on-site or by telephone. As a leading RIA specialist company, we strive to deliver sustainable solutions in select fields of specialties. We therefore continue and remain committed to offer RIA specialty assays in the field of Endocrinology.

IBL-America is able to offer you alternative kits corresponding with the discontinued DiaSorin, Siemens DPC RIA kit and others. For assays with specific requirements on sensitivity which are covered by RIA technology only or by preference, we are confident that our assay kit menu offers valuable alternatives for these discontinued assays. Please contact us for suitable alternative solutions to your testing needs in the field of endocrinology.

Go to table of alternative kits corresponding with the discontinued DiaSorin, Siemens DPC RIA kit and others.