The complement system is an important part of the innate immune system. It consists of three different activation pathways - classical, alternative and lectin/MBL - and is regulated by complex protein cascades involving more than 35 proteins.
The complement system cooperates closely with the adaptive immune system and cross-talks with the coagulation system.
Having an important role in the fight against infections, and in the development of autoimmune and other diseases, the complement system is a matter of extensive research and topic of innovative and interesting new treatment regimens. Below are some examples of research use.
Drug development - potency of complement-targeted therapies
Our complement assays are recognized for their ability to assess the efficacy of complement targeted therapies, whether the aim is to inhibit or enhance complement functionality in research settings.
Clinical studies - monitoring of complement function/activity
Assessment of complement function is also valuable in the development and optimization of treatment regimens for complement related diseases. Examples are studies evaluating new treatment concepts for diseases involving the complement system, and algorithms for drugs modulating the complement system directly.
Off-target complement reactions
During some circumstances complement activation can be devastating and cause severe reactions such as off-target reactions to a drug candidate, antibody dependent complement activation (ACA), or contribute to graft rejection after transplantation.
More information on our Complement System Solutions here.
Proinsulin is a precursor of insulin that is synthesized in the β cells of the islet of Langerhans in the pancreas. Most of the proinsulin synthesized in the rough endoplasmic reticulum of β cells is stored in the secretory granules. It is cleaved by prohormone converting enzyme (PC 2 and PC 3) and it is [...]
Did you know we offer all components to develop your own Vitamin D assay? Based on your application we can work together with our scientific experts at DIASource ImmunoAssays SA to select the best components from a list of proven materials:One of several Monoclonal Antibodies One antigen, functionalized according to your application Sets of calibrators and controls Displacement [...]
Galactose-deficient IgA1 (Gd-IgA1) attracts a lot of attention as a critical effector molecule in the pathogenesis and progression of IgA nephropathy (IgAN) in many recent studies. It is suggested that several O-link glycans modified regions exist in the heavy chain hinge region of human IgA1 molecules and Gd-IgA1 circulates in blood stream of the patients with [...]
Tau in Alzheimer's Disease (AD) research Tau protein is a 45-50 kDa microtubule-associated protein consisting of 352-441 amino acids. It has a role of stabilizing microtubules that transport intracellular substances in nerve cells. It has been observed that tauopathy such as Alzheimer's type dementia (AD) and frontotemporal lobar degeneration (FTLD) is developed due to abnormal accumulation [...]
The exact measurement of hormone concentrations is important for the correct estimation of the hormone balance and endocrine function. This measurement traditionally is performed in blood/serum/plasma samples. Several hormones also can be analyzed in saliva. This technique offers several advantages: the sampling is non-invasive and can be done anytime, anywhere. Saliva testing for steroid hormones is [...]
Intended use (Research only)Detection of human IgG and IgM antibodies in serum or plasma directed against the lipopolysaccharide (LPS) of Francisella tularensis Support in the detection of tularemia Epidemiological studiesEfficiencyThe evaluation of the IBL Francisella tularensis IgG ELISA was performed in an internal study with 98 serum samples of healthy blood donors, 50 sera from subjects with acute infection and 7 [...]
Our Research Drug Monitoring ELISA Kits are highly sensitive and specific assay tests for determining the concentration of Adalimumab, Infliximab, Rituximab,Tocilizumab and many more in serum and plasma. The Research Drug Monitoring ELISA Assay Kits can be used for university research, pharmaceutical research, or clinical research. Each kit comes with specialized instructions regarding the incubation time [...]
IBL-America will be exhibiting at many conferences this year and we want to meet you! If you will be attending any of the events below, please stop by our booth to see what's new or schedule a meeting with us!MEDLABFebruary 4th - 7thDubai, United Arab EmiratesBooth #Z5 - A30Masonic Cancer Center Research Symposium (University of Minnesota)April [...]
Problem - Risk of a Cardiovascular Event While cholesterol control has been dramatically improved, widely used drugs such as statins, Ezetimibe and PCSK9 inhibitors have not substantially decreased the risk of a cardiovascular event.Significance of TG Control A recent study highlights the significance of triglyceride (TG) control. New drug development that inhibits regulating factors of LPL activity that is critical for [...]