Amyloid-beta is generated through amyloid precursor protein (APP) cleavage by specific secretases. Beta-secretase cleaves an extracellular portion of APP and frees a soluble peptide. Gamma-secretase cleaves APP within the transmembrane domain, creating amyloid-beta (Aβ) isoforms with lengths between 36-43 amino acid residues.
In N3pE amyloid beta isoforms, the 3rd glutmate residue is converted to pyroglutamate. N3pE-40 and N3pE-42 variants may have a higher propensity toward aggregation than unmodified amyloid beta, which has been hypothesized to contribute to the Alzheimer's pathology. The Amyloid Beta ( N3pE-40) ELISA kit (Cat# 27418) selectively detects the N3pE-40 amyloid beta variant, whereas a separate ELISA Kit (Cat# 27716) selectively detects N3pE-42.
Amyloid Beta ( N3pE-40 ) Aβ ELISA (Cat# 27418) -The affinity purified monoclonal antibody percolated on the ELISA plate and the affinity purified polyclonal HRP conjugated detection antibody is selective to AβN3pE-40 with minimal cross-reactivity to N3pE-42. The antibodies have been generated to the N-terminus of AβN3pE-40.
Amyloid Beta ( N3pE-42) Aβ ELISA (Cat# 27716) -The affinity purified monoclonal antibody percolated on the ELISA plate and the affiniy purified polyclonal HRP conjugated detection antibody is selective to AβN3pE-42. The antibodies have been generated to the N-terminus of AβN3pE-42.
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Angiotensinogen Detection Angiotensinogen (also known as serpin peptidase inhibitor, clade A, member 8; Serpin A8, Ang, Ang II, PAT, and ANRT) is a 452-amino acid hormone precursor produced by the liver and is implicated in blood pressure control. Urinary excretion of angiotensinogen in a rat hypertension model indicates that this protein is involved in the intrarenal [...]
Pancreatic Polypeptide (PP) is a 36 amino acid polypeptide that is secreted by PP cells (F cells or γ cells) from the islets of Langerhans of the pancreas and is classified as a NPY family peptide along with Peptide YY (PYY) and Neuropeptide Y (NPY). The receptors of these NPY family consist of 5 subtypes such [...]
Our Anti- Tissue-Transglutaminase ELISA tests from are used for the determination of IgA and/or IgG antibodies against Tissue-Transglutaminase (tTG) in human serum or plasma. The assays Anti-Tissue-Transglutaminase IgA, Anti-Tissue-Transglutaminase IgG, and Anti-Tissue-Transglutaminase Screen support testing of celiac disease. Celiac disease (sprue) is one of the most common food-induced diseases. It manifests itself as hypersensitivity to gluten in food, [...]
TNF inhibitors are a type of drug used worldwide to treat inflammatory conditions such as rheumatoid arthritis (RA), psoriatic arthritis, juvenile arthritis, inflammatory bowel disease (Crohn’s and ulcerative colitis), ankylosing spondylitis, and psoriasis. They reduce inflammation and stop disease progression by targeting an inflammation-causing substance called Tumor Necrosis Factor (TNF). In healthy individuals, excess TNF in [...]
The complement system is an important part of the innate immune system. It consists of three different activation pathways - classical, alternative and lectin/MBL - and is regulated by complex protein cascades involving more than 35 proteins.The complement system cooperates closely with the adaptive immune system and cross-talks with the coagulation system.Having an important role in the [...]
Proinsulin is a precursor of insulin that is synthesized in the β cells of the islet of Langerhans in the pancreas. Most of the proinsulin synthesized in the rough endoplasmic reticulum of β cells is stored in the secretory granules. It is cleaved by prohormone converting enzyme (PC 2 and PC 3) and it is [...]
Did you know we offer all components to develop your own Vitamin D assay? Based on your application we can work together with our scientific experts at DIASource ImmunoAssays SA to select the best components from a list of proven materials: One of several Monoclonal AntibodiesOne antigen, functionalized according to your applicationSets of calibrators and controlsDisplacement [...]
Galactose-deficient IgA1 (Gd-IgA1) attracts a lot of attention as a critical effector molecule in the pathogenesis and progression of IgA nephropathy (IgAN) in many recent studies. It is suggested that several O-link glycans modified regions exist in the heavy chain hinge region of human IgA1 molecules and Gd-IgA1 circulates in blood stream of the patients with [...]
*First time users: Contact us for a special offerTau in Alzheimer's Disease (AD) research Tau protein is a 45-50 kDa microtubule-associated protein consisting of 352-441 amino acids. It has a role of stabilizing microtubules that transport intracellular substances in nerve cells. It has been observed that tauopathy such as Alzheimer's type dementia (AD) and frontotemporal lobar degeneration [...]