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Alpha Klotho ELISA Kits

Alpha Klotho (α-Klotho) is a key player that integrates a multi-step regulatory system of calcium metabolism and phosphate homeostasis. 

Alpha-Klotho is an increasingly studied biomarker with an ever growing list of cited publications. We have compiled a list of some of these publicatons which can be found by clicking the following link: 

Alpha Klotho Publications

 

Alpha Klotho (α-Klotho) was identified as an extremely down-regulated gene in the genetic mutation mouse (Klotho mouse) of which phenotype is very similar to various symptoms of human aging. Then, the sequences of Alpha Klotho (α-Klotho) genes have been identified in various species including human based on the one of mouse. α-Klotho protein is a 130kDa, one-transmembrane protein and its expression is confirmed in the kidneys and the parathyroid glands.

In recent years, it has become clear that α-Klotho is an important molecule within a living organism regulating the metabolism of mineral such as calcium and phosphorus. Therefore, it is considered that, in Klotho mouse, early aging-like symptoms are induced by impaired mineral homeostasis caused by decreased expression of α- Klotho.

Meanwhile, it is reported that the long N-terminal extracellular domain which comprises the major portion of sequence of α-Klotho protein is released free into blood by shedding. However, there are may unclear points about functions and changes in concentration of free (soluble) α-Klotho protein, so it has been required to develop the measurement system of α-Klotho.

We offer a solid phase sandwich ELISA for the determination of human soluble Alpha Klotho (α-Klotho) in serum and EDTA-plasma and a solid phase sandwich ELISA for the determination of mouse soluble Alpha Klotho (α-Klotho) in mouse urine. A newly developed sandwich ELISA has also been released to detect Human Secreted Alpha Klotho (α-Klotho) in serum, EDTA plasma, and Cerebrospinal fluids (CSF).

For research use only, not for use in diagnostic procedures.

  • Human soluble Alpha Klotho (α-Klotho) ELISA

    Human soluble Alpha Klotho (α-Klotho) ELISA

    Solid phase sandwich ELISA for the determination of human soluble Alpha Klotho (α-Klotho) in serum and EDTA-plasma. For research use only, not for use in diagnostic procedures. α-Klotho is a key player that integrates a multi-step regulatory...

    $852.00
    Add to Cart
  • Human secreted Alpha Klotho (α-Klotho) ELISA

    Human secreted Alpha Klotho (α-Klotho) ELISA

    Solid phase sandwich ELISA for the determination of human secreted Alpha Klotho ( α-Klotho ) in serum, EDTA-plasma, and cerebrospinal fluids (CSF). For research use only, not for use in diagnostic procedures. α-Klotho (Alpha Klotho) was...

    $852.00
    Add to Cart
  • Mouse soluble Alpha Klotho (α-Klotho) ELISA

    Mouse soluble Alpha Klotho (α-Klotho) ELISA

    Solid phase sandwich ELISA for the determination of mouse soluble Alpha Klotho (α-Klotho) in mouse urine. For research use only, not for use in diagnostic procedures. α-klotho (Alpha Klotho) was identified as an extremely down-regulated gene...

    $852.00
    Add to Cart
  • Human FGF23 ELISA

    Human FGF23 ELISA

    Solid phase sandwich ELISA for the determination of human Fibroblast Growth Factor 23 (FGF23) in human serum or EDTA plasma. For research use only, not for use in diagnostic procedures. The kit can measure both intact FGF23 and FGF23 contained...

    $852.00
    Add to Cart
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