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PDGFRβ (22B1) Anti-Human Mouse IgG MoAb

$550.00
SKU:
10351
Bulk Pricing:
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PDGF, a ligand of PDGFR, has 4 isofoms, A-, B-, C- and D-chains, and forms hetero and/or homo dimers, PDGF-AA, -AB, -BB, -CC, -DD. On the other hand, PDGFR has 2 isoforms, α- and β-chains and forms hetero and/or homo dimers, PDGFR-αα, -αβ and -ββ. PDGF-A and PDGF-C binds specifically to PDGFR-α, PDGF-B binds to PDGFR-α and PDGFR-β, and PDGF-D binds specifically to PDGFR-β. In other words, PDGF-AA and PDGF-CC can activate only PDGF-αα, while PDGF-AB can activate PDGFR-αα and PDGFR-αβ, and PDGF-BB can activate PDGFR-αα, -αβ and -ββ. While, PDGF-DD has been reported to be able to activate PDGFR-αβ as well as PDGFR -ββ. When the receptor is dimerized, tyrosine kinase activity in the intracellular region increases and auto-phosphorylation of the tyrosine residue takes place. For research use only, not for use in diagnostic procedures.

application:
WB, IP, FCM
Catalog number:
10351
clone:
22B1
Datasheet:

Click for Datasheet

formulation:
Lyophilized product from 1% BSA in PBS containing 0.05% NaN3
immunogen:
Recombinant protein of extracellular domain of human PDGFRβ
isotype:
IgG1
MSDS:

Click for MSDS

notes:
For research use only, not for use in diagnostic procedures.
The datasheet for this product (see above) is intended to serve as an example only. Please refer to the datasheet provided with the antibody for precise details.
Protocol:

Click for Antibody Protocol

size:
100 µg
storage:
Lyophilized product, 5 years at 2 - 8 °C; Solution, 2 years at -20 °C
Species:
Human
Host:
Mouse