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Mouse soluble Alpha Klotho (α-Klotho) ELISA
Solid phase sandwich ELISA for the determination of mouse soluble Alpha Klotho (α-Klotho) in mouse urine. For research use only, not for use in diagnostic procedures. α-klotho (Alpha Klotho) was identified as an extremely down-regulated gene...
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Osteopontin
Solid phase sandwich ELISA for the determination of human Osteopontin (Human OPN) in plasma (EDTA), urine, or cell culture media. For research use only, not for use in diagnostic procedures. Osteopontin (OPN) is a secreted glycoprotein that was...
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Osteopontin (10A16) Anti-Human Mouse IgG MoAb
Osteopontin (OPN) is a secreted glycoprotein that was originally isolated from bone. Its molecular weights have been reported in the range of 66 kDa to 44 kDa depending on glycosylation and phosphorylation. OPN is also known to be expressed in other...
Add to Cart$567.00 -
Osteopontin (1B20) Anti-Human Mouse IgG MoAb
Osteopontin (OPN) is a secreted glycoprotein that was originally isolated from bone. Its molecular weights have been reported in the range of 66 kDa to 44 kDa depending on glycosylation and phosphorylation. OPN is also known to be expressed in other...
Add to Cart$567.00 -
Osteopontin (1B20) Anti-Human Mouse IgG MoAb 1
Osteopontin (OPN) is a secreted glycoprotein that was originally isolated from bone. Its molecular weights have been reported in the range of 66 kDa to 44 kDa depending on glycosylation and phosphorylation. OPN is also known to be expressed in other...
Add to Cart$136.00 -
Osteopontin (Mouse)
Solid phase sandwich ELISA for the determination of Mouse Osteopontin (Mouse OPN) in plasma (EDTA), urine, or cell culture media. For research use only, not for use in diagnostic procedures. Osteopontin (OPN) is a secreted glycoprotein that was...
Add to Cart$654.00 -
Osteopontin (O-17) Anti-Human Rabbit IgG Affinity Purify
Osteopontin (OPN) is a secreted glycoprotein that was originally isolated from bone. Its molecular weights have been reported in the range of 66 kDa to 44 kDa depending on glycosylation and phosphorylation. OPN is also known to be expressed in other...
Add to Cart$567.00 -
Osteopontin (O-17) Anti-Human Rabbit IgG Affinity Purify 1
Osteopontin (OPN) is a secreted glycoprotein that was originally isolated from bone. Its molecular weights have been reported in the range of 66 kDa to 44 kDa depending on glycosylation and phosphorylation. OPN is also known to be expressed in other...
Add to Cart$136.00 -
Osteopontin (O-17) Anti-Mouse Rabbit IgG Affinity Purify
Osteopontin (OPN) is a secreted glycoprotein that was originally isolated from bone. Its molecular weights have been reported in the range of 66 kDa to 44 kDa depending on glycosylation and phosphorylation. OPN is also known to be expressed in other...
Add to Cart$567.00 -
Osteopontin (O-17) Anti-Mouse Rabbit IgG Affinity Purify 1
Osteopontin (OPN) is a secreted glycoprotein that was originally isolated from bone. Its molecular weights have been reported in the range of 66 kDa to 44 kDa depending on glycosylation and phosphorylation. OPN is also known to be expressed in other...
Add to Cart$136.00 -
Osteopontin (O-17) Anti-Rat Rabbit IgG Affinity Purify
Osteopontin (OPN) is a secreted glycoprotein that was originally isolated from bone. Its molecular weights have been reported in the range of 66 kDa to 44 kDa depending on glycosylation and phosphorylation. OPN is also known to be expressed in other...
Add to Cart$567.00 -
Osteopontin (O-17) Anti-Rat Rabbit IgG Affinity Purify 1
Osteopontin (OPN) is a secreted glycoprotein that was originally isolated from bone. Its molecular weights have been reported in the range of 66 kDa to 44 kDa depending on glycosylation and phosphorylation. OPN is also known to be expressed in other...
Add to Cart$136.00
Nephrology
Nephrology is the study of the kidney, including both normal kidney function and kidney diseases. The Renin-Angiotensin-Aldosterone System (RAAS), also known as the Renin-Angiotensin System (RAS), is a multi-hormonal system that coordinates a variety of physiological processes for proper regulation of blood volume and pressure. RAAS regulates sodium and water absorption in the kidney, thus directly impacting systemic blood pressure.
Typically, RAAS is activated when a drop in blood pressure (reduced blood volume) occurs to increase water and electrolyte reabsorption in the kidneys, which compensates for the drop in blood volume and increases blood pressure.
When renin is released into the blood, it acts upon a circulating substrate, angiotensinogen, that undergoes proteolytic cleavage to form the decapeptide angiotensin I. Vascular endothelium, particularly in the lungs, has an enzyme, angiotensin converting enzyme (ACE), that cleaves off two amino acids to form the octapeptide, angiotensin II (AII), although many other tissues in the body (heart, brain, vascular) also can form AII.
The one-dimensional standard of kidney disease detection is incompatible with the complexity of renal pathology. The diagnosis of kidney disease has largely focused on glomerular filtration, while assessment of kidney tubular health has notably been absent. Kidney tubular cells undergo a cascade of cellular responses that result in the production and accumulation of low-molecular-weight proteins in the urine and systemic circulation. Recent advancements in molecular analysis and proteomics have allowed the identification and quantification of these proteins as biomarkers for studying kidney diseases.
IBL-America offers a variety of unique biomarker assays that may be useful while studying acute kidney injury (AKI) and chronic kidney diseases (CKD).
- Measurement of Galactose-deficient IgA1 (Gd-IgA1) levels may provide information on the pathogenesis of IgA nephropathy (IgAN), a leading renal disease.
- Klotho levels are decreased in AKI and CKD.
- Uromodulin is exclusively produced by the kidneys and is the most abundant protein in normal urine.
- Complement has been shown to have roles in immune-complex glomerulonephritis and the pathogenesis of many non-immune-complex mediated kidney diseases.
Please contact us to learn more about our ELISA offerings available for AKI and CKD research.