Solid phase sandwich ELISA designed for the determination of T-Cadherin (100k, 130k) in human serum and EDTA-plasma. For research use only, not for use in diagnostic procedures. <br> <br>
T-Cadherin is a protein that binds to Adiponectin (APN), an adipocyte-secreted factor.
APN binds to and accumulates in aorta, heart, skeletal muscle, and mesenchymal stem cells in systemic tissues via T-Cadherin, and is thought to promote exosome production and exert a protective effect on organ tissues. In addition, SNPs near the T-Cadherin gene are strongly associated with glucose intolerance and cardiovascular disease risk in humans.
Recently, it was reported that soluble T-Cadherin exists in human blood in three forms: 130kDa, 100kDa, and 30kDa. These three soluble forms of T-Cadherin correlate with various clinical parameters in patients with type 2 diabetes, and their concentrations change rapidly in the acute phase of myocardial infarction, so they are expected to be useful as biomarkers.
In addition, soluble T-Cadherin has been found to promote the proliferation of pancreatic beta cells and inhibit the decline in insulin secretory capacity, and its function as a humoral factor is also in focus.
We provide 3 ELISA kits that measure (1) 130kDa molecular species only, (2) 30kDa + 130kDa molecular species, and (3) 100kDa + 130kDa molecular species.