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Mammalian cells transport glucose through a family of membrane proteins known as glucose transporters (GLUTs or SLC2A family). Mammalian tissues are known to express different glucose transporter isoforms (exisiting at least GLUTs 1-13) in different tissues. The molecular weight are 40-60 kDa, respectively. GLUT-1 has a high affinity with glucose (Km 1-5 mM) and mediates glucose transport into red cells, and throughout the blood brain barrier. It is ubiquitously expressed and transport glucose in most cells, such as red cells, embryo tissues, brain, kidney or tumor cells. GLUT-3 has a high affinity with glucose (Km 1 -5 mM) and is the main transporter in brain (neurons). GLUT-5 transports fructose in intestine and testis. Especially, our GLUT-5 antibody detects microglia selectively in immnostaining, and doesn't react with monocytes and monocyte-derived macrophages. Immunostaining by this antibody excels in the form observation compared with staining by other antibodies reported as microglia markers, and it makes it easy to distinguish between a static type and an active type in the form observation.
Mammalian cells transport glucose through a family of membrane proteins known as glucose transporters (GLUTs or SLC2A family). Mammalian tissues are known to express different glucose transporter isoforms (exisiting at least GLUTs 1-13) in different tissues. The molecular weight are 40-60 kDa, respectively. GLUT-1 has a high affinity with glucose (Km 1-5 mM) and mediates glucose transport into red cells, and throughout the blood brain barrier. It is ubiquitously expressed and transport glucose in most cells, such as red cells, embryo tissues, brain, kidney or tumor cells. GLUT-3 has a high affinity with glucose (Km 1 -5 mM) and is the main transporter in brain (neurons). GLUT-5 transports fructose in intestine and testis. Especially, our GLUT-5 antibody detects microglia selectively in immnostaining, and doesn't react with monocytes and monocyte-derived macrophages. Immunostaining by this antibody excels in the form observation compared with staining by other antibodies reported as microglia markers, and it makes it easy to distinguish between a static type and an active type in the form observation.