CDCrel-1 (C354) Anti-Human Rabbit IgG Affinity Purify 1

Parkinson's Disease (PD) is a relatively common neurodegenerative disorder, which is characterized by the loss of midbrain dopamine (DA) neurons and the presence of Lewy bodies, proteinaceous cytoplasmic inclusions that are abundantly enriched in ubiquitin. It is identified a number of potential substrates for parkin, which may be involved in the pathogenesis of PD. One of parkin's potential substrates is CDCrel-1. Mutations in parkin impair its ability to regulate the turnover of CDCrel-1. CDCrel-1 belongs to a family of septin GTPases and may regulate synaptic vesicle release in the nervous system. For research use only, not for use in diagnostic procedures.