Pancreatic Polypeptide (PP) is a 36 amino acid polypeptide that is secreted by PP cells (F cells or γ cells) from the islets of Langerhans of the pancreas and is classified as a NPY family peptide along with Peptide YY (PYY) and Neuropeptide Y (NPY).
The receptors of these NPY family consist of 5 subtypes such as Y1, Y2, Y4, Y5 and Y6 and PP has an especially high affinity with the Y4 receptor. It has been known as a satiety factor that suppresses appetite by acting on the Y4 receptor in the hypothalamus.
Recently, it has been reported that PP possibly acts as a blood glucose control factor that suppresses the secretion of glucagon by acting on the Y4 receptor of alpha cells after glucose loading.
It's also considered that PP is secreted through stimulation of the vagus nerve after meals and is involved in the regulation of food intake. A highly specific antibody is required for PP studies since PP cells produce both PP and PYY along with the high homology of the amino acid sequences.
This antibody specifically reacts to PP in Human, Rat and Mouse and it can be used for Immunohistochemistry (Immunofluorescence staining and DAB staining) against PP cells of the islets of Langerhans.