The cookie settings on this website are set to 'allow all cookies' to give you the very best experience. Please click Accept Cookies to continue to use the site.

N3pE Amyloid-beta Isoform Assays

Jun 26th 2019

N3pE Amyloid-beta Isoform AssaysAmyloid-beta is generated through amyloid precursor protein (APP) cleavage by specific secretases. Beta-secretase cleaves an extracellular portion of APP and frees a soluble peptide. Gamma-secretase cleaves APP within the transmembrane domain, creating amyloid-beta (Aβ) isoforms with lengths between 36-43 amino acid residues. 

In N3pE amyloid beta isoforms, the 3rd glutmate residue is converted to pyroglutamate. N3pE-40 and N3pE-42 variants may have a higher propensity toward aggregation than unmodified amyloid beta, which has been hypothesized to contribute to the Alzheimer's pathology. The Amyloid Beta ( N3pE-40) ELISA kit (Cat# 27418) selectively detects the N3pE-40 amyloid beta variant, whereas a separate ELISA Kit (Cat# 27716) selectively detects N3pE-42. 


Amyloid Beta ( N3pE-40 ) Aβ ELISA (Cat# 27418) -The affinity purified monoclonal antibody percolated on the ELISA plate and the affinity purified polyclonal HRP conjugated detection antibody is selective to AβN3pE-40 with minimal cross-reactivity to N3pE-42. The antibodies have been generated to the N-terminus of AβN3pE-40.


Amyloid Beta ( N3pE-42) Aβ ELISA (Cat# 27716) -The affinity purified monoclonal antibody percolated on the ELISA plate and the affiniy purified polyclonal HRP conjugated detection antibody is selective to AβN3pE-42. The antibodies have been generated to the N-terminus of AβN3pE-42.


Contact us for a first time user discount today.

OUR ASSAY KIT CATEGORIES