ELISA Kit for IL-36γ (Specific Marker for Psoriasis) 

IL-36γ is a specific marker for Psoriasis. This assay is highly specific for human IL-36γ. Does not cross-react with human IL-36α and IL-36β.

Sensitivity: 3 pg/ml | Range: 3.9 to 250 pg/ml | Sample: Serum, Cell Culture Supernatant

IL-36α (IL-1F6), IL-36β (IL-1F8) and IL-36γ (IL-1F9) are members of the IL-1 cytokine family that bind to IL-36R (IL-1Rrp2) and IL-1RAcP, activating similar intracellular signals as IL-1 and are inhibited by IL-36Ra. The expression of IL-36 cytokines occurs mainly in the lung and skin and can be derived from diverse epithelial cell types including keratinocytes, bronchial epithelium as well as macrophages, monocytes and different T cell subsets. IL-36 family members induce the production of pro-inflammatory cytokines, including IL-12, IL-1β, IL-6, TNF-α and IL-23, thus promoting neutrophil influx, dendritic cell (DC) activation, polarization of T helper type 1 (Th1) and IL-17-producing T cells (αβ T cells and γδ T cells) and keratinocyte proliferation. Induction of IL-36γ in macrophages upon M. tuberculosis infection and its role in the release of antimicrobial peptides has been proposed. IL-36γ is also induced in the lung in various models of asthma and can be produced by bronchial epithelial cells in response to viral infection, smoke or inflammatory cytokines and plays an important role in asthmatic pulmonary inflammation. IL-36γ might be a potential biomarker of Inflammatory Bowel Disease and is highly expressed in inflamed skin from psoriasis subjects and in Allergic Contact Dermatitis. IL-36γ serum levels are enhanced and correlate to psoriasis severity and response to treatment with anti-TNF.

IL-36γ (human) ELISA Kit (IB99529)

ELISA Kit for IL-37 (A New Anti-inflammatory IL-1 Family Member)

IL-37 is a new anti-inflammatory cytokine. This assay detects natural and recombinant monomeric and dimeric human IL-37.

Sensitivity: 10 pg/ml | Range: 16 to 1000 pg/ml | Sample: Serum, Plasma

IL-37 (IL-1F7; IL-1H4) is an IL-1 family member that is expressed only in certain types of human organs and cells such as heart, thymus, testis, kidney, mononuclear cells (PBMCs) and dendritic cells. IL-37 is an inhibitor of innate immunity with anti-inflammatory properties. It binds to the interleukin-18 receptor (IL-18R) and its co-receptor SIGIRR. IL-37 is secreted as a full-length and as a processed form starting from amino acid Val46. It plays an important role as a link between innate and adaptive immunity and acts as an inhibitor of autoimmune diseases and tumor growth. IL-37 also inhibited Lipopolysaccharide (LPS)-induced immunological reaction and LPS-induced osteoclast formation and bone resorption. A recent study indicates that IL-37 protein forms a head-to-head homodimer and this structure limits its bioactivity. Variants with mutations converting the cytokine into a monomeric form are 13 fold more active than the dimeric IL-37.

IL-37 (human) ELISA Kit (IB99511)

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