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Anti-Bevacizumab (Avastin®)

$1,110.00
SKU:
TM09012
Bulk Pricing:
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ImmunoGuide® Enzyme immunoassay (ELISA) test kit for the determination of free antibodies to Bevacizumab in serum and plasma.<br><br>

The drug Bevacizumab (trade name Avastin®) is a recombinant human IgG1:monoclonal antibody specific for all human vascular endothelial growth factor-A (VEGF-A) isoforms and it has been approved by the FDA as a first-line treatment for metastatic colorectal cancer in combination with chemotherapy. Furthermore, VEGF is implicated in intraocular neovascularization associated with diabetic retinopathy and age-related macular degeneration. As with all therapeutic proteins, there is a potential for immunogenicity. According to the manufacturer’s product insert; the incidence of antibody development in patients receiving Bevacizumab has not been adequately determined because the assay sensitivity was inadequate to reliably detect lower titers.<br><br>

The ImmunoGuide Antibody to Bevacizumab ELISA Kit can be used for monitoring anti-Bevacizumab antibodies during therapy and offers the clinician a tool for decision on possible preventive measures. For research use only, not for use in diagnostic procedures.

Assay Description:
1 hour incubation (RT) + 1 hour (RT) + 15 min. (RT) = 2 hours, 15 min. total incubation time
Catalog number:
TM09012
configuration:
96 Determinations, 12x8 removable strips
controls:
Positive control
design:
Enzyme immunoassay (ELISA) technique
FDA Status:
For research use only, not for use in diagnostic procedures
MSDS:
Available upon request
notes:
The protocol for this product (see above) is intended to serve as an example only. Please refer to the Instructions For Use provided with the assay kit for precise details.
Protocol:

Protocol

Sample types:
Serum and plasma
Sample volume:
10 µL
Standards:
5 Standards, ready to use
Standard range:
0 / 30 - 1000 ng/mL
storage:
2 - 8 °C
sensitivity:
40 ng/mL
Species:
Human
Products related:
Bevacizumab (Avastin®) ELISA
Bevacizumab (Avastin®) (mAb-based) ELISA
Additional info:

Pamphlet