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Amyloid Beta ( N ) ( 82E1 ) Aβ Anti-Human Mouse IgG MoAb

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Product Description

Alzheimer’s disease (AD) is characterized by the presence of extracellular plaques and intracellular neurofibrillary tangles (NFTs) in the brain. The major protein component of these plaques is beta amyloid peptide (Aβ), a 40 to 43 amino acid peptide cleaved from amyloid precursor protein by beta-secretase and a putative γ-secretase. Increased release of the ‘longer forms’ of Aβ peptide, Aβ42 or Aβ43, which have a greater tendency to aggregate than Aβ40, occurs in individuals expressing certain genetic mutations, expressing certain ApoE alles, or may involve other still undiscovered factors. Many researchers theorize that it is this increased release of Aβ42/Aβ 43 which leads to the abnormal deposition of Aβ and the associated neurotoxicity in the brains of affected individuals. This antibody specifically reacts human Aβ N-terminal end, therefore it is very useful to detect APP fragments generated by β-secretase cleavage.

List Price: $499.00
QTY
SKU:
10323

Product Description

Alzheimer’s disease (AD) is characterized by the presence of extracellular plaques and intracellular neurofibrillary tangles (NFTs) in the brain. The major protein component of these plaques is beta amyloid peptide (Aβ), a 40 to 43 amino acid peptide cleaved from amyloid precursor protein by beta-secretase and a putative γ-secretase. Increased release of the ‘longer forms’ of Aβ peptide, Aβ42 or Aβ43, which have a greater tendency to aggregate than Aβ40, occurs in individuals expressing certain genetic mutations, expressing certain ApoE alles, or may involve other still undiscovered factors. Many researchers theorize that it is this increased release of Aβ42/Aβ 43 which leads to the abnormal deposition of Aβ and the associated neurotoxicity in the brains of affected individuals. This antibody specifically reacts human Aβ N-terminal end, therefore it is very useful to detect APP fragments generated by β-secretase cleavage.

Other Details

application:
IHC, WB, Immunoprecipitation
Catalog number:
10323
clone:
820
concentration:
100 μg/mL
Datasheet:
formulation:
Lyophilized product from 1% BSA in PBS containing 0.05% NaN3
immunogen:
Synthetic peptide for Human Amyloid (1-16) (DAEFRHDSGYEVHHQK)
isotype:
Mouse-Mouse hybridoma (supernatant) (X63-Ag8.653×BALB/c mouse spleen cells)
notes:
For research use only, not for use in diagnostic procedures.
The datasheet for this product (see above) is intended to serve as an example only. Please refer to the datasheet provided with the antibody for precise details.
Other names:
Please see datasheet.
size:
50 µg
storage:
Lyophilized product, 5 years at 2 – 8 °C, Solution, 2 years at –20 °C
Species:
Human
Host:
Mouse
Additional info:

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