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Amyloid Beta E22P ( 11A1 ) Aβ Anti-Human Mouse IgG MoAb

Product Description

Alzheimer’s disease (AD) is characterized by the presence of extracellular plaques and intracellular neurofibrillary tangles (NFTs) in the brain. Aggregation of the 42-mer amyloid β-protein (Aβ42) plays a critical role in the pathogenesis of AD. Shirasawa and Irie et. al have proposed a toxic conformer with a turn at positions 22 and 23, as well as a nontoxic conformer with a turn at positions 25 and 26, in Aβ42 aggregates from systematic proline scanning and solid-state NMR studies (ref. 1-3). This monoclonal antibody named 11A1 was developed for toxic Aβ42, using E22P-Aβ10-35, a minimum moiety for neurotoxicity containing the turn at positions 22 and 23, for the generation. Immunohistochemical studies showed that not only extracellular but intracellular amyloid was stained in human AD brains (ref. 4), which suggest that 11A1 could detect toxic oligomers of Aβ with the turn at positions 22 and 23.

List Price: $499.00
QTY
SKU:
10379

Product Description

Alzheimer’s disease (AD) is characterized by the presence of extracellular plaques and intracellular neurofibrillary tangles (NFTs) in the brain. Aggregation of the 42-mer amyloid β-protein (Aβ42) plays a critical role in the pathogenesis of AD. Shirasawa and Irie et. al have proposed a toxic conformer with a turn at positions 22 and 23, as well as a nontoxic conformer with a turn at positions 25 and 26, in Aβ42 aggregates from systematic proline scanning and solid-state NMR studies (ref. 1-3). This monoclonal antibody named 11A1 was developed for toxic Aβ42, using E22P-Aβ10-35, a minimum moiety for neurotoxicity containing the turn at positions 22 and 23, for the generation. Immunohistochemical studies showed that not only extracellular but intracellular amyloid was stained in human AD brains (ref. 4), which suggest that 11A1 could detect toxic oligomers of Aβ with the turn at positions 22 and 23.

Other Details

application:
IHC, WB, immuno-precipitation.
Catalog number:
10379
clone:
11A1
concentration:
Please see datasheet.
Datasheet:
formulation:
Lyophilized product from PBS containing 1 % BSA and 0.05 % NaN3
immunogen:
Synthetic peptide of E22P- Amyloid Beta Aβ 10-35 part
isotype:
IgG1
notes:
For research use only, not for use in diagnostic procedures.
The datasheet for this product (see above) is intended to serve as an example only. Please refer to the datasheet provided with the antibody for precise details.
Other names:
Please see datasheet.
size:
50 μg
storage:
Lyophilized product, 5 years at 2 - 8 °C; Solution, 2 years at -20 °C.
Species:
Human
Host:
Mouse
Additional info:

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