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Amyloid Beta ( 35-40 ) ( 1A10 ) Aβ Anti-Human Mouse IgG MoAb

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Product Description

Alzheimer’s disease (AD) is characterized by the presence of extracellular plaques and intracellular neurofibrillary tangles (NFTs) in the brain. The major protein component of these plaques is beta amyloid peptide (Aβ), a 40 to 43 amino acid peptide cleaved from amyloid precursor protein by β-secretase and a putative γ-secretase. Increased release of the ‘longer forms’ of Aβ peptide, Aβ42 or Aβ43, which have a greater tendency to aggregate than Aβ40, occurs in individuals expressing certain genetic mutations, expressing certain ApoE alleles, or may involve other, still undiscovered, factors. Many researchers theorize that it is this increased release of Aβ42/Aβ43 which leads to the abnormal deposition of Aβ and the associated neurotoxicity in the brains of affected individuals.

List Price: $499.00
QTY
SKU:
10047

Product Description

Alzheimer’s disease (AD) is characterized by the presence of extracellular plaques and intracellular neurofibrillary tangles (NFTs) in the brain. The major protein component of these plaques is beta amyloid peptide (Aβ), a 40 to 43 amino acid peptide cleaved from amyloid precursor protein by β-secretase and a putative γ-secretase. Increased release of the ‘longer forms’ of Aβ peptide, Aβ42 or Aβ43, which have a greater tendency to aggregate than Aβ40, occurs in individuals expressing certain genetic mutations, expressing certain ApoE alleles, or may involve other, still undiscovered, factors. Many researchers theorize that it is this increased release of Aβ42/Aβ43 which leads to the abnormal deposition of Aβ and the associated neurotoxicity in the brains of affected individuals.

Other Details

application:
IHC, WB.
Catalog number:
10047
clone:
1A10
concentration:
1.0 mL deionized water will be added to the product, then its concentration comes to 50 μg/mL.
Datasheet:
formulation:
Lyophilized product in PBS containing 1 % BSA and 0.05 % NaN3.
immunogen:
Synthetic peptide of human Amyloid Beta Aβ (35-40) (MVGGVV).
isotype:
IgG1
notes:
For research use only, not for use in diagnostic procedures.
The datasheet for this product (see above) is intended to serve as an example only. Please refer to the datasheet provided with the antibody for precise details.
Other names:
Aβ, Amyloid beta, A-beta.
size:
50 µg
storage:
Lyophilized product, 5 years at 2 - 8°C; Solution, 2 years at -20°C.
Species:
Human
Host:
Mouse
Additional info:

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