Imai et al. have found that S. cerevisiae Sir2p and its higher eukaryotic orthologs are novel nicotinamide adenine dinucleotide (NAD)-dependent histone/protein deacetylases. Sir2 proteins promote longevity in yeast and in C. elegans by silencing rDNA and regulating the insulin/IGF-1 signaling pathway, respectively. The enzymatic activities and functions of Sir2 proteins are highly conserved in evolution. In 2001, Vaziri, H. et al. have found that mammalian Sir2 negatively regulates the p53 function by physically interacting with and deacetylating the protein. This aspect of Sir2 function may connect various cellular damages, such as oxidative stress, to aging and carcinogenesis. For research use only, not for use in diagnostic procedures.
- application:
- IHC, WB, IP
- Catalog number:
- 18761
- Datasheet:
- formulation:
- Lyophilized product from 1% BSA in PBS containing 0.05% NaN3
- immunogen:
- Synthetic peptides for part of C Terminal of human Sir2/SIRT1 (LEDEPDVPERAGG)
- MSDS:
- notes:
- For research use only, not for use in diagnostic procedures.
The datasheet for this product (see above) is intended to serve as an example only. Please refer to the datasheet provided with the antibody for precise details. - Other names:
- Please see datasheet
- Protocol:
- purification:
- Purified with antigen peptides
- size:
- 100 µg
- specificity:
- Confirmed by western blotting
- storage:
- Lyophilized product, 5 years at 2 - 8 °C, Solution, 2 years at -20 °C
- Species:
- Human
- Host:
- Rabbit
- References:
