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sAPPβ-sw (6A1) Anti-Human Mouse IgG MoAb

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Product Description

Amyloidβ is derived by the sequential cleavage of amyloid precursor protein (APP) by betaand gamma-secretases. A double missense mutation (Lys670→Asn and Met671→Leu) in APP found in a Swedish pedigree (APPβ-sw) elevates Abeta40 and Abeta42 production (1), and the mutation is utilized in establishment of transgenic mice overexpress a mutant form of human amyloid precursor protein (2). Amyloidβproduction and, beta-secretase cleavage of APP β -sw reportedly occur in the endoplasmic reticulum (ER), Golgi and endocytic compartments (3).
List Price: $499.00
QTY
SKU:
10321

Product Description

Amyloidβ is derived by the sequential cleavage of amyloid precursor protein (APP) by betaand gamma-secretases. A double missense mutation (Lys670→Asn and Met671→Leu) in APP found in a Swedish pedigree (APPβ-sw) elevates Abeta40 and Abeta42 production (1), and the mutation is utilized in establishment of transgenic mice overexpress a mutant form of human amyloid precursor protein (2). Amyloidβproduction and, beta-secretase cleavage of APP β -sw reportedly occur in the endoplasmic reticulum (ER), Golgi and endocytic compartments (3).

Other Details

application:
WB, Immunoprecipitation.
Catalog number:
10321
clone:
6A1
concentration:
Please see datasheet.
data_sheet_pdf:
formulation:
Lyophilized product from 1% BSA in PBS containing 0.05%NaN3
immunogen:
Synthetic peptide for C-Terminal of Human sAPPβ-sw (ISEVNL)
isotype:
IgG3
Msds pdf:
notes:
For research use only, not for use in diagnostic procedures.
The datasheet for this product (see above) is intended to serve as an example only. Please refer to the datasheet provided with the antibody for precise details.
Other names:
Soluble βAmyloid Precursor Protein -Swedish
size:
100 μg
storage:
Lyophilized product, 5 years at 2 – 8 ℃, Solution, 2 years at –20 ℃
filter:
Human
host_type:
Mouse
Additional info:

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