The cookie settings on this website are set to 'allow all cookies' to give you the very best experience. Please click Accept Cookies to continue to use the site.

Prorenin Receptor Protein & The RAA System

Posted by Brandon Savela on Aug 16th 2018

(Pro)renin receptor/(P)RR is a common receptor protein between renin and prorenin. When prorenin binds to (P)RR, it achieves a binding ability to angiotensinogen and gains a catalytic activity for conversion from angiotensinogen to ansiotensin I in a comparable level with renin. Additionally, when the (P)RR is stimulated by binding to prorenin, its intracellular signaling progresses. Through this, (P)RR research is believed to have an important implication in building new strategies for the suppression of an overactivated RAA (Renin-Angiotensin-Aldosterone) system.

(P)RR is a 39 kDa, single transmembrane receptor protein and it is reported that the 29 kDa soluble form is generated by cleavage of (P)RR with furin. Thus the assay of soluble (P)RR in blood or urine samples is expected to provide new knowledge to help clarification of disease mechanisms and development of new tools for diseases. This ELISA kit can measure the concentration of human soluble (pro)renin receptor in blood or urine samples.

Soluble (Pro)renin Receptor ELISA

Catalog Number 27782
Species Human
Design Solid phase sandwich ELISA using 2 kinds of highly specific antibodies.
Standards 8 standards, serially diluted from 1 prepared lyophilized standard.
Controls None provided.
Sample Types Human: serum, EDTA-plasma, urine.
Mouse and Rat: serum, EDTA-plasma.
Cell culture supernatant.
Sample Volume 100 μL of properly diluted unknown / determination.
Assay Desc. Overnight incubation (4°C) + 1 hour (4°C) + 30 min. (RT) = Overnight + 1 hour, 30 min. total incubation time.
Standard Range 0 / 125 - 8000 pg/mL
Sensitivity 24 pg/mL
Storage 2 - 8 °C
Configuration 96 Determinations, 12x8 removable strips
FDA Status For research use only, not for use in diagnostic procedures.

OUR ASSAY KIT CATEGORIES