Prion Protein (C) Anti-Human Rabbit IgG Affinity Purify

The prion protein (Prp) is a protein of unknown function that is expressed in both normal cells and in cells affected by Transmissible spongioform encephalopathies (TSEs) which are lethal neurodegenerative diseases affecting numerous mammals. TSEs are characterized by the conversion of the cellular protein PrPC to the disease-associated variant, PrPSC. The PrPC and PrPSC proteins share the same primary sequence and have no known posttranslational differences, and are believed to differ in folding conformation. PrpSC is found in high quantity in the brains of animals affected by TSEs, including scrapie in sheep, BSE in cattle and Creutzfeld-Jacob disease in humans. For research use only, not for use in diagnostic procedures.