LRRK2 Anti-Human Rabbit IgG Affinity Purify

Parkinson’s disease is one of the most common neurodegenerative disease and characterized by progressive loss of dopaminergic neurons. Leucine-rich repeat kinase 2 (LRRK2) is one of the responsible gene of autosomal dominant Parkinson’s disease. LRRK2 gene codes about 280 kDa protein with 2,527 amino-acid residues and has Leucine-rich repeats, Roc (Ras of complex proteins), COR (C-terminal of Roc), MAPKKK (mitogen-activated protein kinase kinase kinase) and WD40 domains. In recent studies, it has been reported that LRRK2 protein has a kinase activity and the activity increases by a mutation of LRRK2 gene. And the increase of kinase activity has been shown to induce neurologic toxicity. However, there are many unclear points about functions of LRRK2 protein, and its role in pathogenic mechanism of Parkinson’s disease is still unknown. For research use only, not for use in diagnostic procedures.