Lag (Langerhans Cells), (4D12) Anti-Human Mouse IgG MoAb

Langerhans cells (LC) were reported to function as the antigen-presenting cells in the skin. They express immune response gene-associated antigens on their cell membranes. These cells seem to mediate contact sensitivity in vivo and the antigen-specific response of T lymphocytes in vitro. Langerhans cells also have surface receptors for the Fc portion of immunoglobulin G (IgG) and for the third component of complement, C3. They originate from the bone marrow, but details about the precursors of LC are not known. This antibody reacts specifically to human LC. The protein recognized by this antibody was mainly in the membranes of Birbeck granules and related structures. For research use only, not for use in diagnostic procedures.