IBL-America is pleased to announce the release of 2 Titin N-Fragment Assay kits. 

Titin (connectin) is a protein that consists of 34,350 amino-acid (3,816kDa) and is specifically expressed in cross-striated muscle. Titin has been known as the largest protein among of existing proteins in a living body. It has been researched in the field of muscular damages such as sports medicine, cardiac disease, NAFLD, sarcopenia and frailty etc. 

Sarcopenia with NAFLD (Non-Alcoholic Fatty Liver Disease) is a progressive and systemic loss of skeletal muscle mass and decreased muscle strength. NAFLD is a disease where there is accumulation of excess fat in the liver (fatty liver) of people who drink little or no alcohol. 

A relationship between decreased skeletal muscle mass and the worsening of life prognosis in chronic liver disease, in hepatocellular carcinoma has recently been reported. It has been also reported that decreased muscle mass is a risk for developing NAFLD (Non-Alcoholic Fatty Liver Disease) and liver fibrosis in NAFLD patients, and increased muscle mass is associated with improvement of NAFLD pathological conditions. 

Titin is a long elastic protein mainly located at cross striated muscle. Titin is cleaved and released into blood and urine when muscles are damaged.

Possibility Non-Invasive Biomarker for ALS

The study reported that Urinary Titin N-fragment levels normalized with Cr (titin/Cr) were significantly high in ALS (Amyotrophic Lateral Sclerosis) patients, that were associated with the scores of motor functions ALSFRS-R　(r=-0.422, p<0.001), and patients with high Titin N-fragment showed poor prognosis.  https://pubmed.ncbi.nlm.nih.gov/33737450/

View More Publication References

ELISA Kit:
Human Titin N-Fragment Assay Kit - IBL (#27900)
Mouse Titin N-Fragment Assay Kit – IBL (#27602)

Antibodies:
Anti-Titin-N (53A1) Mouse IgG MoAb (#10423)
Anti-Titin-N (144A2) Mouse IgG MoAb (#10425)
*These antibodies specifically react to human Titin N-Fragment and can be used in ELISA application.