Specifically detects Human secreted α-Klotho isoform

The α-Klotho gene was identified as a gene with extremely reduced expression in genetically mutated mice with a phenotype that closely resembles the diverse aging symptoms of humans.

The long N-terminal extracellular domain, which occupies most of the sequence of the α-Klotho protein, has been reported to be shedding and released in the blood, while secretory isoform with only first repeat by gene splicing
(secreted α-Klotho) has been reported.

This kit specifically measures human secreted isoforms (secreted α-Klotho) in human serum, EDTA-plasma and cerebrospinal fluid and does not react with soluble α-Klotho derived from transmembrane α-Klotho.

Since there are many unclear points regarding the function of secreted α-Klotho protein and its body fluids concentration, we hope the kit will contribute to further research of secreted α-Klotho.

The Human secreted α-Klotho Assay Kit specifically detects particular isoforms called “secreted α-Klotho”.

#27901 Human secreted α-Klotho Assay Kit  - Only detect secreted α-Klotho

#27998 Human soluble α-Klotho Assay Kit - Detect all soluble α-Klotho isoforms which contains KL1 domain including secreted α-Klotho.

You can distinguish secreted α-Klotho and bunch of soluble α-Klotho isoform which contains KL1 domain.

Learn more about the Human secreted Alpha Klotho (α-Klotho) ELISA

* This kit is for research use only, not for use in diagnostic procedures