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New Product Release | 3-Methoxytyramine RIA Kit

Posted by Brandon Savela on Jul 13th 2017

3-METHOXYTYRAMINE PLASMA RIA FAST TRACK (3-MT RIA) (IB88528)

ADVANTAGES:

  • New biomarker of phaeochromocytoma and paraganglioma tumours
  • The first commercial assay worldwide!
  • Speed and ease of use
  • 48 duplicate determinations or 96 single
  • Easy sample preparation (extraction)
  • No known interferences by medical drugs
  • High correlation with LC/MS-MS
  • Wide standard ranges, convenient measurement of pathological samples without predilution


COMPARISON LC-MS/MS: 3-Methoxytyramine RIA vs LC-MS/MS

ESSENTIAL INFORMATION

Cells derived from neuroendocrine tumors (e.g. pheochromcytoma) are known to produce catecholamines which are secreted episodically via vesicles into the bloodstream. Along with this, a small portion of the catecholamines is metabolized inside the cells to the corresponding catecholamines metabolites – namely metanephrine, normetanephrine and 3-methoxytyramine (3-MT) – which are secreted at low levels continuously into the bloodstream. 3-methoxytyramine is a metabolite of the neurotransmitter Dopamine formed by the introduction of a methyl group to dopamine by the enzyme catechol-O-methyl transferase (COMT). The measurement of 3-MT allows the detection of dopamine-producing tumors: For example a substantial number of subjects with head-and-neck paragangliomas (HNPGL) have biochemically active tumors and only display increased excretion of 3-MT, but not of other catecholamines or their metabolites. The combined levels of free metanephrine/normetanephrine and free 3-MT in plasma indicate a higher number of biochemically active HNPGLs than the 24-h urinary excretion rates of these markers. In addition, 3-MT acts as a neuromodulator and can also induce behavioral effects involved in movement control in a dopamine independent manner. Most of these effects are mediated by the trace amine associated receptor 1 (TAAR1) which in turn is involved in abnormal dopaminergic transmission, such as Parkinson's disease, dyskinesia and schizophrenia. The 3­-Methoxytyramine RIA is designed for research use only and should not be used in diagnostic procedures.

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