ImmunoGuide® Enzyme immunoassay (ELISA) test kit for the determination of free antibodies directed against the drug Trastuzumab (Herceptin®, Herclon®) in serum and plasma.<br><br>
The drug Trastuzumab (trade names Herceptin®, Herclone®) is a recombinant DNA-derived humanized monoclonal antibody that selectively targets the extracellular domain of the human epidermal growth factor receptor 2 protein (HER2). The antibody is an IgG1 kappa that contains human framework regions with the complementarity-determining regions of a murine anti-p185 HER2 antibody that binds to HER2.<br><br>
According to the prescribing information, the use of Trastuzumab might be associated to the development of anti-Trastuzumab antibodies in various percentages of patients during therapy with the drug.<br><br>
The ImmunoGuide Antibody to Trastuzumab ELISA Kit can be efficiently used for monitoring Anti-Trastuzumab antibodies during therapy and offers the clinician a tool for decision on possible preventive measures. For research use only, not for use in diagnostic procedures.