Anti-Tob (4B1) Mouse IgG MoAb

Tob (Transducing molecule of c-ErbB-2) was identified as a molecule that binds to the receptor tyrosine kinase c-ErbB2 in 1996. After that, Tob2, BTG1, PC3/TIS21/BTG2, ANA, PC3B etc were found as proteins with a homologous region at about 110 amino acids on the N-terminal side, and are called Tob family proteins.<br><br>

Tob family proteins are known to suppress cell proliferation when compulsorily expressed in cultured cells. This proliferative suppression occurs by blocking the expression of cyclin D1. On the other hand, Tob is rapidly phosphorylated at Ser152, Ser154 and Ser164 by Erk1/2 upon growth-factor stimulation. It is suggested that this phosphorylation cancels the suppression of cyclin D1 expression.<br><br>

Thus, it is to thought be Tob and its phosphorylation have important role in the progression from G0 to G1 in the cell cycle. For research use only, not for use in diagnostic procedures.