Alzheimer's disease (AD) is a typical senile dementia and it is believed that accumulation of Amyloidβ (Aβ) in brain parenchyma is a major cause of the disease. Meanwhile, accumulation of Aβ has been also observed on cerebrovascular walls of nearly 90% of individuals suffering with AD. Aβ is known to be produced from Amyloid Precursor Protein (APP) by cleavage with two types of protease (β- and γ- secretase) and Aβ molecules which accumulate in brain parenchyma are mainly produced from APP expressed in neurons, APP695. In contrast to this, another different APP, APP770, was found to be expressed in cerebrovascular endothelial cells, and it has been newly reported that the Aβ produced from the APP770 can accumulate on cerebrovascular walls (ref. 1). This antibody recognizes human APP770. For research use only, not for use in diagnostic procedures.
- application:
- IHC, WB
- Catalog number:
- 28133
- Datasheet:
- formulation:
- Lyophilized product in PBS containing 1% BSA and 0.05% NaN3
- immunogen:
- Synthetic peptide of a part of human APP770
- MSDS:
- notes:
- For research use only, not for use in diagnostic procedures.
The datasheet for this product (see above) is intended to serve as an example only. Please refer to the datasheet provided with the antibody for precise details. - Other names:
- Please see datasheet
- Protocol:
- purification:
- Purified with antigen peptide
- size:
- 100 µg
- specificity:
- Please see datasheet
- storage:
- Lyophilized product, 5 years at 2 - 8 °C; Solution, 2 years at -20 °C.
- Species:
- Human
- Host:
- Rabbit
- Additional info:
