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The drug Certolizumab pegol (trade name Cimzia®) is a tumor necrosis factor alpha (TNFα) blocker and binds to human TNFα with a KD of 90pM. Certolizumab pegol is a recombinant, humanized antibody … read more

The drug Ranibizumab (trade name Lucentis®) is a recombinant humanized IgG1 kappa isotype monoclonal antibody fragment (Fab) designed for intraocular use. Ranibizumab binds to and inhibits the bio … read more

(Pro)renin receptor/(P)RR is a common receptor protein between renin and prorenin. It has an ability equivalent to renin to bind angiotensinogen and a catalytic activity for conversion from angiot … read more

Background The complement system plays an essential role in chronic, autoimmune and infectious disease. There are three pathways of complement activation, namely the classical, the alternativ … read more

Researchers at University of California, San Francisco (UCSF) are taking an innovative approach to battling neurodegenerative diseases like Alzheimer’s disease and dementia. Rather than trying to u … read more