sAPPα (Mouse/Rat) (highly sensitive)
- SKU:
- 27419
- Bulk Pricing:
-
- Buy 5 - 20 and get 5% off
- Buy 21 - 30 and get 10% off
- Buy 31 - 50 and get 15% off
- Buy 51 or more – call for best pricing
The cookie settings on this website are set to 'allow all cookies' to give you the very best experience. Please click Accept Cookies to continue to use the site.
Solid phase sandwich ELISA for the determination Mouse/Rat sAPPα in serum, EDTA plasma and cell culture supernatant. For research use only, not for use in diagnostic procedures. <br><br>
Alzheimer’s disease (AD) was first reported by A. Alzheimer, a German neuropathologist in 1907 and is considered as a major factor of dementia. It is known that Amyloid β (Aβ; which is major constituent of senile plaque) is cleaved from Amyloid Precursor Protein (APP; which exists in three main isoforms, APP695, APP751, and APP770) by β-secretase and subsequent γ-secretase. The production of soluble APPβ (sAPPβ) by β-secretase cleavage corresponds to Aβ production accordingly, so it is desired to measure sAPPβ in parallel with Aβ. On the other hand, it is considered that in the metabolic pathway of APP, APP is first cleaved by α-secretase rather than β-secretase normally to produce soluble APPα (sAPPα) and subsequently P3 is cleaved from the remaining C-terminal fragment by γ-secretase. In recent research, there are several attempts to apply the inhibitor of β-secretase and the activation of α-secretase for AD treatment. As stated above, it is useful for research of AD to measure sAPPα as well as sAPPβ. This kit can measure Mouse/Rat sAPPα. Note: Please pay attention in sample selection since this kit also measures full-length APP.
Solid phase sandwich ELISA for the determination Mouse/Rat sAPPα in serum, EDTA plasma and cell culture supernatant. For research use only, not for use in diagnostic procedures. <br><br>
Alzheimer’s disease (AD) was first reported by A. Alzheimer, a German neuropathologist in 1907 and is considered as a major factor of dementia. It is known that Amyloid β (Aβ; which is major constituent of senile plaque) is cleaved from Amyloid Precursor Protein (APP; which exists in three main isoforms, APP695, APP751, and APP770) by β-secretase and subsequent γ-secretase. The production of soluble APPβ (sAPPβ) by β-secretase cleavage corresponds to Aβ production accordingly, so it is desired to measure sAPPβ in parallel with Aβ. On the other hand, it is considered that in the metabolic pathway of APP, APP is first cleaved by α-secretase rather than β-secretase normally to produce soluble APPα (sAPPα) and subsequently P3 is cleaved from the remaining C-terminal fragment by γ-secretase. In recent research, there are several attempts to apply the inhibitor of β-secretase and the activation of α-secretase for AD treatment. As stated above, it is useful for research of AD to measure sAPPα as well as sAPPβ. This kit can measure Mouse/Rat sAPPα. Note: Please pay attention in sample selection since this kit also measures full-length APP.