Insulin (Total)
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Chemiluminescence Immunoassay (LUM) for the determination of Total Insulin in mouse/rat EDTA-plasma and serum. For research use only, not for use in diagnostic procedures.<br><br>
Insulin is a peptide hormone that is released from the beta cells of the islets of Langerhans in the pancreas. It is synthesized as an 86 amino-acid precursor “proinsulin”. It is cleaved by C-peptide and insulin that consists of 21 amino-acid A-chain and 30 amino-acid β chain that is linked by disulfide binding due to activation of prohormone conversion enzyme (PC2, PC3) in secretory granules. Insulin deposits glucose and promotes protein synthesis in skeletal muscles. It also has physiological function such as suppressing gluconeogenesis in the liver and is known as the only hormone that can decrease blood glucose. Insulin is constantly released to maintain the level of blood glucose while it is also released in large amount stimulated by incretin and glucose for suppressing rapidly increased blood glucose after meals. However, lack of insulin secretion and decreased insulin sensitivity are observed and eventually high blood glucose is observed in diabetic conditions. Measuring insulin in fasting (F-IRI) is required for assessment of diabetes such as function of insulin secretion and insulin resistance.
Chemiluminescence Immunoassay (LUM) for the determination of Total Insulin in mouse/rat EDTA-plasma and serum. For research use only, not for use in diagnostic procedures.<br><br>
Insulin is a peptide hormone that is released from the beta cells of the islets of Langerhans in the pancreas. It is synthesized as an 86 amino-acid precursor “proinsulin”. It is cleaved by C-peptide and insulin that consists of 21 amino-acid A-chain and 30 amino-acid β chain that is linked by disulfide binding due to activation of prohormone conversion enzyme (PC2, PC3) in secretory granules. Insulin deposits glucose and promotes protein synthesis in skeletal muscles. It also has physiological function such as suppressing gluconeogenesis in the liver and is known as the only hormone that can decrease blood glucose. Insulin is constantly released to maintain the level of blood glucose while it is also released in large amount stimulated by incretin and glucose for suppressing rapidly increased blood glucose after meals. However, lack of insulin secretion and decreased insulin sensitivity are observed and eventually high blood glucose is observed in diabetic conditions. Measuring insulin in fasting (F-IRI) is required for assessment of diabetes such as function of insulin secretion and insulin resistance.