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Vitamin D & Bone Metabolism Assays

Vitamin D & Bone Metabolism Assays

Vitamin D is the generic term used to designate Vitamin D2 or ergocalciferol and Vitamin D3 or cholecalciferol. Humans naturally produce Vitamin D3 when the skin is exposed to ultraviolet sun rays. In the liver mainly, Vitamin D3 is metabolised into 25-Hydroxyvitamin D3 (25OH D3) which is the main form of Vitamin D circulating in the body. 25OH D3 is a precursor for other Vitamin D metabolites and has also a limited activity by itself. The most active derivative is 1,25-hydroxyvitamin D3, produced in the kidney (or placenta) by 1-hydroxylation of 25OH D3. 25OH Vitamin D stimulates the intestinal absorption of both calcium and phosphorus and also bone resorption and mineralisation.

25OH Vitamin D might also be active in other tissues responsible for calcium transport (placenta, kidney, mammary gland) and endocrine gland (parathyroid glands, beta cells). Vitamin D3 and Vitamin D2 are also available by ingestion through food or dietary supplementation. As Vitamin D2 is metabolised in a similar way to Vitamin D3, both contribute to the overall Vitamin D status of an individual. It is the reason why it is very important to measure both forms of 25OH Vitamin D equally for a correct diagnosis of Vitamin D deficiency, insufficiency or intoxication. Vitamin D deficiency is an important risk factor for rickets, osteomalacia, senile osteoporisis, cancer and pregnancy outcomes.The measurement of both 25OH Vitamin D forms is also required to determine the cause of abnormal serum calcium concentrations in subjects. Vitamin D intoxication has been shown to cause kidney and tissue damages.
Item Method / Catalog # Species Price
1,25(OH)2 Vitamin D Extraction Kit
REAGENT SET
3019700
$435
25(OH) Vitamin D2/D3 MoAb, Clone 281/A2KC4
1 mg
5319716
$795
25(OH) Vitamin D2/D3 MoAb, Clone 281/A2LB5
1 mg
5319726
$795
25(OH) Vitamin D2/D3 MoAb, Clone 281/A2NE3
1 mg
5319706
$795
Alpha Klotho (α - Klotho) Human Soluble ELISA Assay Kit
ELISA
27998
$750
Alpha Klotho (α-Klotho) Soluble (Mouse)
ELISA
27601
$750
Total Vitamin D derivative - Amino (NH2)
1 mg
5019703
$795
Total Vitamin D derivative - Biotin
1 mg
5019708
$795
Total Vitamin D derivative - BSA
1 mg
5019701
$1,195
Total Vitamin D derivative - Carboxylic acid (COOH)
1 mg
5019700
$795
Vitamin D (25OH) (Free)
ELISA
KAPF1991
$795
Vitamin D (25OH) Total
ELISA
KAP1971
$375
Vitamin D (25OH) Total (Rat)
ELISA
KRR1971
$1,095
Vitamin D 1,25(OH)2
RIA CT
KIR1929
$629
Vitamin D 1,25(OH)2
ELISA
KAR1921
$895
Vitamin D, 25-OH Total
RIA CT
KIR1971
$580
Vitamin D3, 25-OH
RIA CT
KIP1961
$529