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14-3-3 epsilon Antibody (Clone AT4F8)

The 14-3-3 family of proteins plays a key regulatory role in signal transduction, checkpoint control, apoptotic and nutrient-sensing pathways. 14-3-3 proteins are highly conserved and ubiquitously expressed. There are at least seven isoforms, beta, gamma, epsilon, sigma, zeta, tau and eta that have been identified in mammals. The 14-3-3 epsilon, a subtype of the 14-3-3 family of proteins, was thought to be brain and neuron-specific. It has been shown to interact with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. It has also been implicated in the pathogenesis of small cell lung cancer.
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100 µL
IBATGA0124

Additional Information

Data Sheet

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MSDS
Additional Info
Protocol PDF Link
Catalog Number IBATGA0124
Species Human
Host Type Mouse
Size 100 µL
Immunogen Recombinant human14-3-3 epsilon (1-255aa) purified from E. coli
Isotype IgG2b, k
Clone Anti-human 14-3-3 epsilon mAb, clone AT4F8, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human 14-3-3 epsiilon protein.
Concentration 1 mg/ml
Formulation Liquid. In Phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% Glycerol.
Application ELISA, WB, Flow cytometry, ICC/IF
Storage 4°C. For long term storage, aliquot and store at -20°C.
Other Names Tyrosine 3-monooxygenase/ tryptophan 5-monooxygenase activation protein epsilon polypeptide, YWHAE, MDS, MDCR, KCIP-1, FLJ45465, 14-3-3 epsilon.
Notes For research use only, not for use in diagnostic procedures.
The datasheet for this product (see above) is intended to serve as an example only. Please refer to the datasheet provided with the antibody for precise details.
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