Anti-GFAT1 (663) Rabbit IgG Affinity Purify

GFAT1 (Glutamine : fructose-6-phosphate amidotransferase 1) is one of nutrient-　sensitive　phosphoprotein which was identified as a protein phosphorylated in glucose-deprived cells. Three nutrient signaling pathways have been widely known; (i) the mammalian target of rapamycin (mTOR) signaling pathway, (ii) AMP-activated protein kinase (AMPK) signaling pathway, and (iii) hexosamine signaling pathway. GFAT1 was isolated, which is the first and rate-limiting enzyme for the entry of glucose into the hexosamine signaling pathway to generate UDP-GlcNAc in mammals. Recent evidences have indicated that the signals derived from nutrients like amino acid and glucose play important roles in the control of the cellular activities as well as in synthesis of proteins and generation of ATP. For research use only, not for use in diagnostic procedures.